Adramacenteredonamandealingwiththeaftereffectsofbeinginacomacausedbyacaraccident.WheretheRoadMeetstheSunisthepowerfulandmovingstoryoffourdisparatemenwhoselivesbrieflyintersectinarundownHollywoodHotel.Afterwakingfromafour-yearcoma,Takashi,aJapanesehitman,struggleswithmysteriousandtraumaticmemories.HestrikesanunusualfriendshipwithBlake(EricMabius),thehotelmanager.MeanwhileJulio,anillegalimmigrant,befriendsGuy,ayoungBritlivingoffofhisfathersmoney.Whatfollowsarethewildandgut-wrenchingadventuresoffourmentryingtosurvivethemostdifficulttimeoftheirlives.
